Jiang F C, Ma W D, Cheng S C
School of Pharmacy, Tongji Medical University, Wuhan.
Yao Xue Xue Bao. 1992;27(2):150-2.
Some beta-germanyl-alpha-amino acid derivatives were prepared from the reaction of HGeCl3 with substituted oxazolines. The compositions of the above compounds were studied using IR, element analysis and so on. Experimental results were as follows: for 1-substituted-2-amino-2-carboxyethylgermanium susquioxide (such as IIIb), the po LD50 for mice was found to be above 10 g/kg. When given ip, a maximum inhibition of 50% of the growth of S180 was obtained for IIIb, whereas an inhibition of 42% was achieved for 5-Fu under the same experimental condition.
通过HGeCl3与取代恶唑啉的反应制备了一些β-锗烷基-α-氨基酸衍生物。使用红外光谱、元素分析等方法研究了上述化合物的组成。实验结果如下：对于1-取代-2-氨基-2-羧乙基锗倍半氧化物（如IIIb），发现其对小鼠的半数致死量（LD50）高于10 g/kg。腹腔注射时，IIIb对S180生长的最大抑制率为50%，而在相同实验条件下5-氟尿嘧啶的抑制率为42%。
