Jensen K, Ohrstrøm J, Cold G E, Astrup J
Department of Neuroanesthesia, Arhus Kommunehospital, Denmark.
Acta Neurochir Suppl (Wien). 1992;55:47-8. doi: 10.1007/978-3-7091-9233-7_14.
In five head-injured patients with cerebral contusion and oedema in whom it was not possible to control ICP by hyperventilation and barbiturate sedation, indomethacin (Confortid) was used as a cerebral vasoconstrictor drug. In all patients indomethacin reduced ICP to below 20 mmHg for several hours. Studies of cerebral circulation and metabolism during indomethacin treatment showed a decrease in cerebral blood flow (CBF) at 2 hours. After 7 hours, ICP remained below 20 mmHg in three patients, and these still had reduced CBF. In two patients a return of ICP and CBF to pretreatment levels was observed. In all patients indomethacin treatment was followed by a fall in rectal temperature. Outcome scaling has not yet been performed, but all patients left hospital without neurological deficits. The results suggest, that indomethacin is an alternative in the treatment of ICP-hypertension in head-injured patients.
在5例脑挫伤和脑水肿的头部受伤患者中，通过过度换气和巴比妥类镇静无法控制颅内压（ICP），吲哚美辛（康富利德）被用作脑血管收缩药物。在所有患者中，吲哚美辛使ICP在数小时内降至20 mmHg以下。吲哚美辛治疗期间的脑循环和代谢研究显示，2小时时脑血流量（CBF）下降。7小时后，3例患者的ICP仍低于20 mmHg，且这些患者的CBF仍降低。在2例患者中，观察到ICP和CBF恢复到治疗前水平。所有患者接受吲哚美辛治疗后直肠温度均下降。尚未进行结果评分，但所有患者出院时均无神经功能缺损。结果表明，吲哚美辛是治疗头部受伤患者ICP升高的一种替代方法。
