朗格汉斯细胞组织细胞增多症下丘脑 - 垂体轴的磁共振成像
MR of the hypothalamic-pituitary axis in Langerhans cell histiocytosis.
作者信息
Maghnie M, Aricò M, Villa A, Genovese E, Beluffi G, Severi F
机构信息
Department of Pediatrics, University of Pavia, IRCCS Policlinico S. Matteo, Italy.
出版信息
AJNR Am J Neuroradiol. 1992 Sep-Oct;13(5):1365-71.
PURPOSE
To describe the MR findings in the hypothalamic pituitary area in children with Langerhans cell histiocytosis and to define those MR alterations especially associated with the risk of developing diabetes insipidus.
METHODS
The hypothalamic-neurohypophyseal axis was studied by sagittal and coronal 1.5 T1-weighted MR imaging in 14 children with Langerhans cell histiocytosis (five with diabetes insipidus) and in 28 low-stature controls, ages 6-14 years.
RESULTS
The pituitary stalk was thicker in seven/14 patients (three with diabetes insipidus) than in controls (P less than .05). Bright posterior pituitary signal was undetectable in children with diabetes insipidus and in one/9 without diabetes insipidus.
CONCLUSIONS
Thickening of the hypothalamus and/or the pituitary stalk in the absence of the posterior pituitary bright signal is seen in children with Langerhans cell histiocytosis with overt diabetes insipidus. Those Langerhans cell histiocytosis patients without diabetes insipidus but showing thickened stalk with or without posterior pituitary bright signal could be at high risk to develop diabetes insipidus.
目的
描述朗格汉斯细胞组织细胞增多症患儿下丘脑垂体区的磁共振成像（MR）表现，并确定那些特别与发生尿崩症风险相关的MR改变。
方法
对14例朗格汉斯细胞组织细胞增多症患儿（5例有尿崩症）和28例6 - 14岁身材矮小的对照儿童进行矢状位和冠状位1.5 T T1加权MR成像，研究下丘脑 - 神经垂体轴。
结果
14例患者中有7例（3例有尿崩症）垂体柄比对照组厚（P小于0.05）。尿崩症患儿及9例无尿崩症患儿中的1例未检测到垂体后叶高信号。
结论
在患有明显尿崩症的朗格汉斯细胞组织细胞增多症患儿中可见下丘脑和/或垂体柄增粗且无垂体后叶高信号。那些无尿崩症但显示垂体柄增粗且有或无垂体后叶高信号的朗格汉斯细胞组织细胞增多症患者可能有发生尿崩症的高风险。
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