TAKEMORI S, KING T E
Science. 1964 May 15;144(3620):852-3. doi: 10.1126/science.144.3620.852.
The activity of a particulate succinate cytochrome c reductase is inhibited by antimycin, 2-heptyl-4-hydroxyquinoline-N-oxide, 2-(9-cyclohexyl-n-nonyl)-3-hydroxy-1,4naphthoquinone and thenoyltrifluoroacetone. The ratio of antimycin A (required for complete inhibition) to the molar content of the cytochrome b of the reductase is approximately 0.5 in contrast to the reported value of 1.0 or higher for succinate oxidase preparations. However, the degreeof inhibition by antimycin is dependent on the exogenous coenzyme Q (ubiquinone) present. Indeed, the inhibition from any of these compounds is competitively reversed by exogenous coenzyme Q in the system.
颗粒状琥珀酸细胞色素c还原酶的活性受到抗霉素、2-庚基-4-羟基喹啉-N-氧化物、2-(9-环己基-正壬基)-3-羟基-1,4-萘醌和噻吩甲酰三氟丙酮的抑制。与琥珀酸氧化酶制剂报道的1.0或更高的值相比，抗霉素A（完全抑制所需）与还原酶细胞色素b的摩尔含量之比约为0.5。然而，抗霉素的抑制程度取决于体系中存在的外源性辅酶Q（泛醌）。实际上，体系中任何一种此类化合物的抑制作用都可被外源性辅酶Q竞争性逆转。
