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用同种移植后获得的免疫血清对人淋巴细胞进行血清学分型

SEROLOGIC TYPING OF HUMAN LYMPHOCYTES WITH IMMUNE SERUM OBTAINED AFTER HOMOGRAFTING.

作者信息

WALFORD R L, GALLAGHER R, SJAARDA J R

出版信息

Science. 1964 May 15;144(3620):868-70. doi: 10.1126/science.144.3620.868.

DOI:10.1126/science.144.3620.868
PMID:14149404
Abstract

Serums obtained from paired humans following reciprocal fourthset skin homografts, or from a prolonged series of reciprocal intradermalinjections of leukocytes, displayed potent cytotoxic activity againstlymphocytes of certain individuals and no activity against lymphocytes of other persons. Study of one family suggested that lymphocyte reactivity may be transmitted according to simple Mendelian genetics. Itis probable that this reactivity reflects and can be used to identifyspecific histocompatibility antigens in man.

摘要

从接受相互四组皮肤同种移植的配对人体中获取的血清,或从一系列长期相互皮内注射白细胞后获取的血清,对某些个体的淋巴细胞显示出强大的细胞毒性活性,而对其他个体的淋巴细胞则无活性。对一个家族的研究表明,淋巴细胞反应性可能按照简单的孟德尔遗传学进行传递。这种反应性很可能反映并可用于识别人类中的特定组织相容性抗原。

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SEROLOGIC TYPING OF HUMAN LYMPHOCYTES WITH IMMUNE SERUM OBTAINED AFTER HOMOGRAFTING.用同种移植后获得的免疫血清对人淋巴细胞进行血清学分型
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