Buemann B, Astrup A, Madsen J, Christensen N J
Research Department of Human Nutrition, Royal Veterinary and Agricultural University, Copenhagen, Denmark.
Am J Clin Nutr. 1992 Oct;56(4):662-70. doi: 10.1093/ajcn/56.4.662.
Twenty-four-hour energy expenditure (EE) and substrate oxidation rates were studied in a respiration chamber in 15 reduced-obese (BMI = 24.7) and 8 nonobese (BMI = 20.1) women. Two experiments were performed, one in which beta-blockade was introduced by propranolol and one with placebo. When adjusted for differences in fat-free mass, no difference in 24-h EE was found between the reduced-obese and nonobese groups in placebo experiments. Propranolol reduced 24-h EE by 2.7% in the reduced-obese group whereas no reduction was seen in the nonobese group. A positive correlation was found between fasting glycerol concentration and lipid oxidation. During daytime, lipid oxidation was reduced and carbohydrate oxidation increased by propranolol only in the nonobese subjects. Propranolol reduced fasting glycerol and free fatty acid concentrations in both groups. Beta-blockade seems to have little effect on sedentary 24-h EE but may have a suppressing effect on lipid combustion.
在呼吸室内对15名体重减轻的肥胖女性（BMI = 24.7）和8名非肥胖女性（BMI = 20.1）进行了24小时能量消耗（EE）和底物氧化率的研究。进行了两项实验，一项是通过普萘洛尔引入β受体阻滞剂，另一项使用安慰剂。在安慰剂实验中，调整无脂肪体重差异后，体重减轻的肥胖组和非肥胖组之间的24小时EE没有差异。普萘洛尔使体重减轻的肥胖组的24小时EE降低了2.7%，而非肥胖组未见降低。空腹甘油浓度与脂质氧化之间存在正相关。仅在非肥胖受试者中，白天普萘洛尔使脂质氧化减少，碳水化合物氧化增加。普萘洛尔降低了两组的空腹甘油和游离脂肪酸浓度。β受体阻滞剂似乎对久坐的24小时EE影响不大，但可能对脂质燃烧有抑制作用。
