血红蛋白多态性：其与白尾鹿红细胞镰变的关系。

HEMOGLOBIN POLYMORPHISM: ITS RELATION TO SICKLING OF ERYTHROCYTES IN WHITE-TAILED DEER.

作者信息

KITCHEN H, PUTNAM F W, TAYLOR W J

出版信息

Science. 1964 Jun 5;144(3623):1237-9. doi: 10.1126/science.144.3623.1237.

DOI:10.1126/science.144.3623.1237

Abstract

Hemoglobins with different electrophoretic mobilities are associated with bizarre shapes seen during ordinary light microscopy of erythrocytes from the white-tailed deer, Odocoileus virginianus; nonsickling is contingent upon a specific hemoglobin. Sickling in vitro, which isproduced to a maximum degree in the presence of oxygen and elevated pH, is not associated with hematological abnormalities or disease despite marked differences in physical characteristics of sickled and nonsickled cells.

摘要

在普通光学显微镜下观察白尾鹿（弗吉尼亚鹿）的红细胞时，具有不同电泳迁移率的血红蛋白与奇异形状相关；非镰状化取决于一种特定的血红蛋白。体外镰状化在有氧气和pH升高的情况下达到最大程度，尽管镰状化和非镰状化细胞的物理特性存在显著差异，但它与血液学异常或疾病无关。