LIM K A, CHAN Y C, PHOON W O, HANAM E
Bull World Health Organ. 1964;30(2):227-40.
A dengue-like illness with marked haemorrhagic manifestations appeared in Singapore in 1960. Its similarity in many respects to the haemorrhagic fevers of Thailand and the Philippines led to its being described as "Singapore haemorrhagic fever".This paper describes the isolation and identification of dengue-type viruses from patients in Singapore between 1960 and 1962. In addition to the conventional complement-fixation and neutralization tests, a new test, called the "sensitized erythrocyte agglutination test", was employed; this test method is described.Altogether 21 dengue-type viruses were isolated, including dengue types 1, 2 and 4. Chikungunya virus, prominent in the Thailand disease, was not detected.The author suggests that study of the epidemiology of haemorrhagic fevers in South-East Asia would cast further light on the transmission of arboviruses.
1960年,新加坡出现了一种伴有明显出血症状的登革热样疾病。它在许多方面与泰国和菲律宾的出血热相似,因此被称为“新加坡出血热”。本文描述了1960年至1962年间从新加坡患者中分离和鉴定登革热病毒类型的过程。除了传统的补体结合试验和中和试验外,还采用了一种新的试验,称为“致敏红细胞凝集试验”;本文对该试验方法进行了描述。共分离出21种登革热病毒类型,包括1型、2型和4型。在泰国疾病中占突出地位的基孔肯雅病毒未被检测到。作者建议,对东南亚出血热流行病学的研究将进一步揭示虫媒病毒的传播情况。