Siew Zhen Yun, Seow Isaac, Lim Xin Rui, Tang Chen Zhe, Djamil Fadhilah Moh, Ong Ghee Khang, Leong Pooi Pooi, Wong Siew Tung, Voon Kenny
School of Pharmacy, University of Nottingham Malaysia, Jalan Broga, 43500, Semenyih, Selangor, Malaysia.
Department of Medical Microbiology, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, 43400, Serdang, Selangor, Malaysia.
Arch Virol. 2025 May 26;170(7):140. doi: 10.1007/s00705-025-06314-5.
Arboviruses are viruses that are transmitted by arthropods such as mosquitoes, ticks, and flies, and most of them are RNA viruses. Vector-borne transmission occurs when an infected arthropod bites a vertebrate host, allowing the virus to enter the bloodstream and initiate infection. Arboviruses are known to cause significant morbidity and mortality in mammals, and at least a hundred of them have been identified as human pathogens. In this review, we provide an updated overview of four prominent arboviruses that are present in Southeast Asia (SEA): dengue virus (DENV), Japanese encephalitis virus (JEV), Zika virus (ZIKV), and chikungunya virus (CHIKV). The epidemiology and pathogenesis of these viruses and the currently used methods for diagnosis, prevention, and treatment of arbovirus infections are discussed in detail. Finally, we summarise the concerns and future considerations for combating these dangerous pathogens.
虫媒病毒是一类通过蚊子、蜱虫和苍蝇等节肢动物传播的病毒，其中大多数是RNA病毒。当受感染的节肢动物叮咬脊椎动物宿主时，就会发生媒介传播，使病毒进入血液循环并引发感染。已知虫媒病毒会在哺乳动物中导致严重的发病率和死亡率，其中至少有一百种已被确定为人类病原体。在本综述中，我们提供了东南亚地区四种主要虫媒病毒的最新概述：登革热病毒（DENV）、日本脑炎病毒（JEV）、寨卡病毒（ZIKV）和基孔肯雅病毒（CHIKV）。详细讨论了这些病毒的流行病学和发病机制，以及目前用于诊断、预防和治疗虫媒病毒感染的方法。最后，我们总结了对抗这些危险病原体的相关问题和未来考量。
