KELEN A E, LESIAK J M, LABZOFFSKY N A
Can Med Assoc J. 1964 Jun 13;90(24):1349-51.
In a widespread outbreak of aseptic meningitis during the summer and early fall of 1961 in Ontario, Echo type 25 virus was found to be the predominant virus type isolated from affected patients. Recovery of Echo 25 virus in several cases from the CSF of patients strongly suggests an etiological relationship between this virus type and the illness. The causative role of the virus was confirmed by demonstration of significant immunological response in patients found to be infected with the virus. The presence of antibodies to Echo 25 virus in about 70% of meningitis patients, from whom no virus was isolated, indicates that the infection in the population of the affected areas was much more prevalent than the number of successful virus isolations would suggest. It is recommended that Echo 25 virus should be added to the series of Echo virus types capable of causing outbreaks of aseptic meningitis.
1961年夏秋时节,安大略省大面积爆发无菌性脑膜炎,从患病患者身上分离出的病毒中,埃可25型病毒是主要病毒类型。在几例患者的脑脊液中发现了埃可25型病毒,这有力地表明了该病毒类型与疾病之间存在病因学关联。在被发现感染该病毒的患者中,显著的免疫反应证实了病毒的致病作用。在约70%未分离出病毒的脑膜炎患者体内存在抗埃可25型病毒抗体,这表明受影响地区人群中的感染远比成功分离出病毒的数量所显示的更为普遍。建议将埃可25型病毒添加到能够引发无菌性脑膜炎爆发的埃可病毒类型序列中。