Masnyk S, Nicák A, Grossmann V
Physiol Bohemoslov. 1977;26(3):235-8.
Changes in the isonicotinic acid hydrazide (INH) concentration in rat blood and brain were studied in correlation to postnatal development in groups of animals aged 21 and 42 days and 3 months. In the first part of the experiments, INH was administered intravenously to all the age groups in a dose of 100 mg/kg. In the second part, the dose was related to extracellular fluid volume, so that the 3-week-old rats were given 154 mg/kg, the 6-week-old animals 129 mg/kg and the 3-month-old animals 100 mg/kg. After a dose of 100 mg/kg, INH levels in the blood of 21-day-old rats were significantly lower than in 42-day-old and adult animals. The brain INH levels did not differ significantly. On relating the dose to the amount of extracellular fluid, there were no significant differences in the blood INH levels, but the levels in the brain of 21- and 42-day-old rats were significantly higher than in 3-month-old animals. Blood volume related to body weight and brain weight did not differ in the various age groups. The authors conclude that the blood-brain barrier for isonicotinic acid hydrazide alters in rats during postnatal development. In young animals (21- and 42-day-old), more INH infiltrates into the CNS than in adult animals.
研究了21日龄、42日龄和3月龄大鼠组中异烟肼（INH）在血液和大脑中的浓度变化及其与出生后发育的相关性。在实验的第一部分，以100mg/kg的剂量对所有年龄组静脉注射INH。在第二部分中，剂量与细胞外液体积相关，因此3周龄大鼠给予154mg/kg，6周龄动物给予129mg/kg，3月龄动物给予100mg/kg。给予100mg/kg剂量后，21日龄大鼠血液中的INH水平显著低于42日龄和成年动物。大脑中的INH水平无显著差异。将剂量与细胞外液量相关联时，血液中的INH水平无显著差异，但21日龄和42日龄大鼠大脑中的水平显著高于3月龄动物。不同年龄组与体重相关的血容量和脑重量无差异。作者得出结论，大鼠出生后发育过程中异烟肼的血脑屏障会发生变化。在幼龄动物（21日龄和42日龄）中，与成年动物相比，更多的INH渗入中枢神经系统。
