单宁及相关化合物对人类免疫缺陷病毒复制的抑制作用。

Inhibition of human immunodeficiency viral replication by tannins and related compounds.

作者信息

Nakashima H, Murakami T, Yamamoto N, Sakagami H, Tanuma S, Hatano T, Yoshida T, Okuda T

机构信息

Department of Microbiology, Tokyo Medical and Dental University School of Medicine, Japan.

出版信息

Antiviral Res. 1992 May;18(1):91-103. doi: 10.1016/0166-3542(92)90008-s.

DOI:10.1016/0166-3542(92)90008-s

PMID:1416904

Abstract

Among 87 chemically defined tannins and related compounds, several hydrolyzable tannins, but not condensed tannins or other lower molecular weight polyphenols, significantly inhibited both the cytopathic effect of human immunodeficiency virus (HIV) and the expression of HIV antigen in human lymphotropic virus type I (HTLV-1)-positive MT-4 cells. The 50% effective concentrations (2.0-4.8 micrograms/ml) of the active compounds were 13- to 15-fold lower than their 50% cytotoxic concentrations. Their anti-HIV activity was demonstrated to be mediated, at least in part, by inhibition of HIV adsorption to the cells.

摘要

在87种化学结构明确的单宁及相关化合物中，几种可水解单宁能显著抑制人类免疫缺陷病毒（HIV）的细胞病变效应以及在I型人嗜T淋巴细胞病毒（HTLV-1）阳性的MT-4细胞中HIV抗原的表达，而缩合单宁或其他低分子量多酚则无此作用。活性化合物的50%有效浓度（2.0 - 4.8微克/毫升）比其50%细胞毒性浓度低13至15倍。已证明它们的抗HIV活性至少部分是通过抑制HIV吸附到细胞上介导的。