Unten S, Ushijima H, Shimizu H, Tsuchie H, Kitamura T, Moritome N, Sakagami H
AIDS Research Center, National Institute of Health, Tokyo, Japan.
Lett Appl Microbiol. 1991 Dec;13(6):251-4. doi: 10.1111/j.1472-765x.1991.tb00621.x.
A sodium hydroxide extract from cacao husk inhibited the cytopathic effect of human immunodeficiency virus type 1 (HIV-1) against HTLV-1-transformed T-cell lines MT-2 and MT-4. It also inhibited syncytium formation between HIV-infected and uninfected lymphoblastoid T-cell line, MOLT-4. The anti-HIV activity was concentrated by membrane filter fractionation to a fraction with molecular weight of 100-300 KDa. Anti-HIV activity of the extract was attributable to interference with the virus adsorption, rather than to inhibition of the virus replication after adsorption.
