Thomas G P, Krishnamurthy A, Thapar G S, Varma R K
Biology Division, I.D.P.L. Research Centre, Hyderabad, India.
Arch Int Pharmacodyn Ther. 1992 Jan-Feb;315:79-86.
The alpha 2-adrenoceptor agonist St-93 was evaluated for its effect on blood glucose levels in Wistar rats. A dose-dependent increase in blood glucose was observed in rats after intraperitoneal administration of St-93. The hyperglycemic effect of St-93 was not altered by prazosin and propranolol, whereas idazoxan significantly inhibited this effect. Pretreatment with reserpine did not affect the hyperglycemic effect of St-93. There was no significant increase in the blood glucose values with St-93 in streptozotocin-diabetic rats. It may be concluded that the hyperglycemia induced by St-93 is mediated through alpha 2-adrenoceptors, possibly located on pancreatic beta-cells.
对α2 -肾上腺素能受体激动剂St - 93在Wistar大鼠体内对血糖水平的影响进行了评估。腹腔注射St - 93后，观察到大鼠血糖呈剂量依赖性升高。哌唑嗪和普萘洛尔未改变St - 93的高血糖作用，而异唑嗪显著抑制了该作用。利血平预处理不影响St - 93的高血糖作用。链脲佐菌素诱导的糖尿病大鼠使用St - 93后血糖值无显著升高。可以得出结论，St - 93诱导的高血糖是通过可能位于胰腺β细胞上的α2 -肾上腺素能受体介导的。
