与卡西酮和左非他明相关的吡咯苯乙酮：合成及药理活性
Pyrrylphenylethanones related to cathinone and lefetamine: synthesis and pharmacological activities.
作者信息
Massa S, Di Santo R, Mai A, Artico M, Pantaleoni G C, Giorgi R, Coppolino M F
机构信息
Dipartimento di Studi farmaceutici, Università di Roma, La Sapienza, Italy.
出版信息
Arch Pharm (Weinheim). 1992 Jul;325(7):403-9. doi: 10.1002/ardp.19923250707.
PMID:1417455
Abstract
The synthesis of various pyrrylphenylethanones resembling cathinone and lefetamine is described starting from 2-chloro-1-(1-methyl-1H-pyrrol-2-yl)-2-phenylethan-1-one. Some derivatives showed good antinociceptic activity, comparable to that of morphine. The neuropsychopharmacological profile of title compounds has been also studied to explore their action on C.N.S.
摘要
描述了从2-氯-1-(1-甲基-1H-吡咯-2-基)-2-苯基乙-1-酮出发合成各种类似卡西酮和左非他明的吡咯基苯乙酮。一些衍生物显示出良好的抗伤害感受活性，与吗啡相当。还研究了标题化合物的神经精神药理学特征，以探索它们对中枢神经系统的作用。
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