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精神药物研究。III. 新型5H-吡咯并[1,2-b][1,2,5]苯并三氮杂苯衍生物的抗抑郁活性及神经精神行为效应

Research on psychotropic agents. III. Antidepressant activity and neuropsychobehavioural effects of new 5H-Pyrrolo[1,2-b][1,2,5]benzotriazepine derivatives.

作者信息

Stefancich G, Artico M, Silvestri R, Pantaleoni G C, Giorgi R, Palumbo G

机构信息

Dipartimento di Studi Farmaceutici, Facoltà di Farmacia, Università di Roma La Sapienza.

出版信息

Farmaco. 1990 Jan;45(1):7-27.

PMID:2337448
Abstract

The synthesis of 5H-pyrrolo[1,2-b][1,2,5]benzotriazepine derivatives related to imipramine and aptazepine antidepressant agents is reported. Pharmacological screening on new tricyclic derivatives showed that in some cases antidepressant effects at equimolecular dose with imipramine are associated with sedative-muscle relaxant activities and antinociception.

摘要

据报道，与丙咪嗪和阿普氮平抗抑郁药相关的5H-吡咯并[1,2-b][1,2,5]苯并三氮杂䓬衍生物的合成。对新的三环衍生物进行的药理筛选表明，在某些情况下，与丙咪嗪等分子剂量的抗抑郁作用与镇静-肌肉松弛活性和抗伤害感受有关。

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