胰岛素抑制外周交感神经末梢去甲肾上腺素的溢出。

Insulin inhibits norepinephrine overflow from peripheral sympathetic nerve ending.

作者信息

Shimosawa T, Ando K, Ono A, Takahashi K, Isshiki M, Kanda M, Ogata E, Fujita T

机构信息

Fourth Department of Internal Medicine, University of Tokyo School of Medicine, Japan.

出版信息

Biochem Biophys Res Commun. 1992 Oct 15;188(1):330-5. doi: 10.1016/0006-291x(92)92389-f.

DOI:10.1016/0006-291x(92)92389-f

PMID:1417853

Abstract

The effects of insulin on peripheral nervous system are unknown. We therefore studied the effects of insulin on sympathetic nerve activity in isolated mesenteric arteries of Sprague-Dawley rats. The overflow of norepinephrine (NE) by electrical stimulation was used as the index of sympathetic nervous system activity. Insulin (0.5 to 1U/l) decreased the NE release in a dose-dependent fashion. This inhibitory effect was, however, reversed by either 5 x 10(-5)M cocaine or 5 x 10(-4)M ouabain treatment. Thus, we postulate that insulin attenuates NE overflow from peripheral sympathetic nerve endings, probably due to enhanced NE reuptake.

摘要

胰岛素对周围神经系统的作用尚不清楚。因此，我们研究了胰岛素对Sprague-Dawley大鼠离体肠系膜动脉交感神经活动的影响。通过电刺激引起的去甲肾上腺素（NE）溢出用作交感神经系统活动的指标。胰岛素（0.5至1U/l）以剂量依赖性方式降低NE释放。然而，5×10（-5）M可卡因或5×10（-4）M哇巴因处理可逆转这种抑制作用。因此，我们推测胰岛素可能通过增强NE再摄取来减弱外周交感神经末梢的NE溢出。