呋咱基-1,4-二氢吡啶及呋咱并环类似物的合成与心血管特性
Synthesis and cardiovascular properties of furazanyl-1,4-dihydropyridines and of furoxanyl analogues.
作者信息
Gasco A M, Fruttero R, Sorba G, Gasco A, Budriesi R, Chiarini A
机构信息
Dipartimento di Scienza e Tecnologia del Farmaco, Università di Torino, Italy.
出版信息
Arzneimittelforschung. 1992 Jul;42(7):921-5.
PMID:1418057
Abstract
A series of furazanyl- and furoxanyl-1,4-dihydropyridines has been synthesized and tested for their cardiovascular activity. The new compounds showed a modest activity in comparison with nifedipine and some selectivity for the myocardial muscle. The most active compound was diethyl 1,4-dihydro-2,6-dimethyl-4-(3-phenyl-4-furoxanyl)-3,5-pyridine dicarboxylate, 4d.
摘要
已经合成了一系列呋咱基和呋咱并[3,4 - b]吡啶基 - 1,4 - 二氢吡啶，并对其心血管活性进行了测试。与硝苯地平相比，这些新化合物显示出适度的活性，并且对心肌有一定的选择性。活性最高的化合物是1,4 - 二氢 - 2,6 - 二甲基 - 4 - (3 - 苯基 - 4 - 呋咱并[3,4 - b]吡啶基) - 3,5 - 吡啶二羧酸二乙酯，即化合物4d。
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