具有强效选择性心动过缓作用的4-杂三环取代的1,4-二氢吡啶类化合物。
4-heterotricyclic substituted 1,4-dihydropyridines with a potent selective bradycardic effect.
作者信息
Rampa A, Chiarini A, Bisi A, Budriesi R, Valenti P
机构信息
Department of Pharmaceutical Sciences, University of Bologna, Italy.
出版信息
Arzneimittelforschung. 1991 Jul;41(7):705-9.
PMID:1772458
Abstract
A series of 4-heterotricyclic substituted 1,4-dihydropyridines were prepared. The compounds were evaluated for inotropic, chronotropic and calcium antagonist properties. The tested compounds are fairly good as calcium antagonists, but exert potent selective bradycardic effects.
摘要
制备了一系列4-杂三环取代的1,4-二氢吡啶。对这些化合物的变力性、变时性和钙拮抗特性进行了评估。测试的化合物作为钙拮抗剂相当有效，但具有强大的选择性心动过缓作用。
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