Dodrill C B, Wilkus R J, Ojemann L M
Regional Epilepsy Center, Harborview Medical Center, University of Washington School of Medicine, Seattle 98104.
Epilepsy Res Suppl. 1992;5:71-5.
Cortical resection surgery for epilepsy is costly, involves risk, and does not result in significant seizure relief in a number of patients. Therefore, it is important to develop methods which will as accurately as possible identify in advance those persons who will or will not be helped by this procedure. From a review of the literature and from a presentation of original data, it is concluded that psychological/neuropsychological variables are valid predictors of cessation of seizures following surgery but that they are only infrequently used. A multidisciplinary, multivariate statistical approach, using EEG findings and psychological/neuropsychological variables in combination, provides the most accurate predictions which are superior to those derived from using either EEG variables or psychological/neuropsychological variables alone. This approach also avoids much of the predictive instability encountered when single variables are evaluated. Since psychological/neuropsychological variables are obtained at low cost and are non-invasive, further evaluation of their role as predictors of seizure relief following surgery is needed.
癫痫的皮质切除术成本高昂，存在风险，而且许多患者术后癫痫发作并未得到显著缓解。因此，开发尽可能准确地提前识别哪些患者会从该手术中获益或无法获益的方法非常重要。通过对文献的回顾和原始数据的呈现，得出的结论是，心理/神经心理变量是术后癫痫发作停止的有效预测指标，但它们的使用频率很低。一种多学科、多变量统计方法，将脑电图结果与心理/神经心理变量结合使用，能提供最准确的预测，优于单独使用脑电图变量或心理/神经心理变量得出的预测。这种方法还避免了评估单一变量时遇到的许多预测不稳定性。由于心理/神经心理变量获取成本低且是非侵入性的，因此需要进一步评估它们作为术后癫痫缓解预测指标的作用。
