Cayré R, Sánchez-Gómez C, Moreno-Rodríguez R A, de la Cruz M V
Departamento de Biología del Desarrollo y Teratogénesis Experimental, Hospital Infantil de México Federico Gómez, D.F., México.
Bol Med Hosp Infant Mex. 1992 Jul;49(7):397-403.
The processes of cellular migration, cellular differentiation and cellular multiplication are studied, since these are the basic developmental processes upon which teratogenic agents act resulting in congenital malformations. We also carefully analyze the interactions between teratogen-embryo in order to establish adequate parameters for analysis of environmental teratogens, as well as experimental teratogenesis and epidemiology. Information on the pathogenesis of congenital malformations obtained from experimental teratology in an adequate biological model, can be extrapolated to the human. The etiology of congenital malformations resulting from environmental teratogens can only be elucidated through epidemiology, since there is species specificity. Such a study must fulfill the following prerequisites: diagnosis of the congenital malformation, ruling out genetic factors in the family tree and determination of the exact time of exposure to the possible teratogen during the pregnancy.
对细胞迁移、细胞分化和细胞增殖过程进行了研究，因为这些是致畸剂作用导致先天性畸形的基本发育过程。我们还仔细分析致畸剂与胚胎之间的相互作用，以便建立用于分析环境致畸剂以及实验性致畸作用和流行病学的适当参数。从适当生物学模型中的实验致畸学获得的关于先天性畸形发病机制的信息，可以外推至人类。由于存在物种特异性，环境致畸剂导致的先天性畸形的病因只能通过流行病学来阐明。这样的研究必须满足以下先决条件：先天性畸形的诊断、排除家族树中的遗传因素以及确定孕期接触可能致畸剂的确切时间。
