Takatsu K
Department of Immunology, University of Tokyo, Japan.
Curr Opin Immunol. 1992 Jun;4(3):299-306. doi: 10.1016/0952-7915(92)90080-x.
Interleukin-5 is a dimeric cytokine that controls the differentiation of B cells into antibody-secreting cells as well as inducing the growth of Ly-1(CD5)+ B cells and B-cell tumors. It also has a major role of the growth and differentiation of eosinophils. Rapid progress has been made during the last year in the delineation of the structure and activities of interleukin-5, and the molecular nature of its functional receptors. Interleukin-5 exerts pleiotropic activities on various target cells through a high-affinity receptor which is composed of two different polypeptide chains, alpha and beta. The alpha chain binds interleukin-5 with low affinity and the beta chain has been identified as the interleukin-3 receptor-like protein and is also the beta chain of the granulocyte-macrophage colony stimulating factor receptor.
白细胞介素-5是一种二聚体细胞因子，它控制B细胞分化为抗体分泌细胞，同时诱导Ly-1(CD5)+ B细胞和B细胞肿瘤的生长。它在嗜酸性粒细胞的生长和分化中也起主要作用。去年在白细胞介素-5的结构和活性以及其功能性受体的分子性质的描述方面取得了迅速进展。白细胞介素-5通过由两条不同多肽链α和β组成的高亲和力受体对各种靶细胞发挥多效性作用。α链以低亲和力结合白细胞介素-5，β链已被鉴定为白细胞介素-3受体样蛋白，也是粒细胞-巨噬细胞集落刺激因子受体的β链。
