血清对肾上腺苯乙醇胺N-甲基转移酶活性的影响。
Effect of serum on adrenal PNMT activity.
作者信息
Matussek N, Deuringer L, Sardas-Trevorrow I
机构信息
Department of Neurochemistry, Psychiatric Hospital, University of Munich, Federal Republic of Germany.
出版信息
J Neural Transm Gen Sect. 1992;89(1-2):135-8. doi: 10.1007/BF01245360.
Humoral mechanism should be responsible for activation of PNMT (phenylethanolamine N-methyltransferase) by CRF (corticotropin-releasing factor) in vivo (Lima and Sourkes, 1987). Small amounts of serum (10 microliters) caused a sig. dose dependent activation of bovine PNMT activity (19.0 +/- 1.8%) changing in Km and Vmax values in vitro. Human/rat or ovine CRF--in high amounts (8.4 nmol) only--increase at the rate of just 10% bovine PNMT activity in vitro. At the moment, we do not know which factor in serum is responsible for the increase in A (adrenalin) synthesis in vitro.
在体内，体液机制可能是促肾上腺皮质激素释放因子（CRF）激活苯乙醇胺N-甲基转移酶（PNMT）的原因（利马和苏尔克斯，1987年）。少量血清（10微升）在体外可引起牛PNMT活性显著的剂量依赖性激活（19.0±1.8%），同时Km和Vmax值发生变化。人/大鼠或羊的CRF——仅在高剂量（8.4纳摩尔）时——在体外仅使牛PNMT活性增加10%。目前，我们尚不清楚血清中的哪种因素导致了体外肾上腺素（A）合成的增加。
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