Bentura M L, Lazcano M A, Zahonero M C, Toledano A
Instituto Cajal, C.S.I.C., Madrid, Spain.
J Neural Transm Gen Sect. 1992;89(1-2):81-92. doi: 10.1007/BF01245354.
Several morphological and immunochemical characteristics of the neurosecretory neurons of the supraoptic nucleus (SON) have been studied of rats treated for 1 month with D-amphetamine sulfate (AMP) (8 mg/kg weight, daily). An increase of SON volume (11%) has been observed as a consequence of the growth of the dorsoventral axis. Neurosecretory neurons increased their nucleolar area (11.4%), their nuclear area (8.3%), and their cytoplasmatic area (18.3%). Vasopressin immunoreaction did not show any differences between treated and control animals, but oxytocin immunostaining displayed an important increase (23.7%) in the neuronal cytoplasm of the treated rats. The SON hypertrophy of the AMP-treated rats corresponded to the hypertrophy/hyperfunction of its oxytocinergic neurons, and could be considered as a new mechanism of the action of the AMP. The results are discussed in relation to the plastic features of the SON and its central (neuronal) and peripheral (hormonal) function.
对每日接受硫酸右苯丙胺（AMP）（8毫克/千克体重）治疗1个月的大鼠视上核（SON）神经分泌神经元的几种形态学和免疫化学特征进行了研究。由于背腹轴的生长，观察到SON体积增加了11%。神经分泌神经元的核仁面积增加了11.4%，核面积增加了8.3%，细胞质面积增加了18.3%。加压素免疫反应在治疗组和对照组动物之间未显示任何差异，但催产素免疫染色显示治疗组大鼠神经元细胞质中有显著增加（23.7%）。AMP治疗大鼠的SON肥大与其催产素能神经元的肥大/功能亢进相对应，可被视为AMP作用的一种新机制。结合SON的可塑性特征及其中枢（神经元）和外周（激素）功能对结果进行了讨论。
