Takeshita M, Mathison M, Yagyu K, Kotsuka Y, Matsunaga H, Furuse A
Department of Thoracic Surgery, Faculty of Medicine, University of Tokyo.
J Cardiol Suppl. 1992;28:133-7; discussion 138.
Two-hundred and eighty-one patients underwent surgical treatment of the aortic valves during a 10-year period of 1981 to 1991, 32 of whom (11%) had bicuspid aortic valve. Bicuspid aortic valve is well known to cause calcified aortic stenosis, however, some of these cases develop pure aortic insufficiency of unknown etiology. In our studies of 32 patients with bicuspid aortic valve, 28 patients had aortic stenosis, 2 were aortic insufficiency and 2 were infective endocarditis. Pathogenesis of aortic insufficiency in patients with bicuspid aortic valves was discussed and compared with that of aortic stenosis.
在1981年至1991年的10年期间，281例患者接受了主动脉瓣手术治疗，其中32例（11%）患有二叶式主动脉瓣。众所周知，二叶式主动脉瓣会导致钙化性主动脉瓣狭窄，然而，其中一些病例会出现病因不明的单纯主动脉瓣关闭不全。在我们对32例二叶式主动脉瓣患者的研究中，28例患有主动脉瓣狭窄，2例患有主动脉瓣关闭不全，2例患有感染性心内膜炎。对二叶式主动脉瓣患者主动脉瓣关闭不全的发病机制进行了讨论，并与主动脉瓣狭窄的发病机制进行了比较。
