高密度脂蛋白（HDL）对体外6-酮-前列腺素F1α（6-keto-PGF1α）和血栓素B2（TXB2）形成的影响：HDL来源的重要性
Influence of HDL on the formation of 6-keto-PGF1 alpha and TXB2 in vitro: the importance of the source of HDL.
作者信息
Beitz J, Beitz A, Müller G, Giessler C, Mest H J
机构信息
Department of Pharmacology and Toxicology, Martin Luther University Halle-Wittenberg, Halle, Federal Republic of Germany.
出版信息
Eicosanoids. 1992;5(1):53-6.
The influence of HDL, isolated from normolipidemic human blood and blood of normo- and hyperlipidemic rabbits, on in vitro 6-keto-PGF1 alpha synthesis by rabbit aorta and on TXB2 synthesis by platelets of clotting human and rabbit blood was tested. The HDL fraction from normolipidemic subjects, when incubated with blood from normolipidemic humans or rabbits, inhibited TXB2 formation. The same fraction stimulated the formation of 6-keto-PGF1 alpha after incubation with rabbit aorta taken from normolipidemic animals. HDL taken from hyperlipidemic rabbits inhibited 6-keto-PGF1 alpha formation in rabbits and had no influence on TXB2 formation. These results support the hypothesis that not only is the absolute amount of HDL important for its influence on prostanoid formation, but also the origin and the composition of the HDL fraction.
研究了从血脂正常的人血液以及血脂正常和血脂异常的兔血液中分离出的高密度脂蛋白（HDL），对兔主动脉体外合成6-酮-前列腺素F1α（6-keto-PGF1α）以及对人凝血血液和兔凝血血液中血小板合成血栓素B2（TXB2）的影响。来自血脂正常受试者的HDL组分，与血脂正常的人或兔的血液一起孵育时，可抑制TXB2的形成。同一组分与取自血脂正常动物的兔主动脉孵育后，可刺激6-酮-前列腺素F1α的形成。从血脂异常的兔中获取的HDL可抑制兔体内6-酮-前列腺素F1α的形成，且对TXB2的形成没有影响。这些结果支持了这样一种假说，即不仅HDL的绝对量对其影响前列腺素类物质的形成很重要，而且HDL组分的来源和组成也很重要。
Zotero 插件