具有降低小鼠骨髓毒性的甲基亚硝基脲抗肿瘤药物的构效关系研究。 - Suppr

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超能文献

Structure-activity studies of methylnitrosourea antitumor agents with reduced murine bone marrow toxicity.

作者信息

Panasci L C, Fox P A, Schein P S

出版信息

Cancer Res. 1977 Sep;37(9):3321-8.

PMID:141978

Abstract

摘要

相似文献

Structure-activity studies of methylnitrosourea antitumor agents with reduced murine bone marrow toxicity.具有降低小鼠骨髓毒性的甲基亚硝基脲抗肿瘤药物的构效关系研究。

Cancer Res. 1977 Sep;37(9):3321-8.

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Biological and biochemical properties of 1-(2-chloroethyl)-3-(beta-D-glucopyranosyl)-1-nitrosourea (NSC D 254157), a nitrosourea with reduced bone marrow toxicity.

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Repair of DNA alkylation induced in L1210 leukemia and murine bone marrow by three chloroethylnitrosoureas.

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A comparison of the biological and biochemical properties of 1-(4-amino-2-methylpyrimidin-5-yl)methyl-3-(2-chloroethyl)-3-nitrosourea and 2-[3-(2-chloroethyl)-3-nitrosoureido]-D-glucopyranose.

Cancer Res. 1978 Jan;38(1):65-8.

DNA damage and repair in mouse leukemia L1210 cells treated with nitrogen mustard, 1,3-bis(2-chloroethyl)-1-nitrosourea, and other nitrosoureas.用氮芥、1,3-双（2-氯乙基）-1-亚硝基脲及其他亚硝基脲处理的小鼠白血病L1210细胞中的DNA损伤与修复

Cancer Res. 1977 Jul;37(7 Pt 1):2114-22.

Pharmacology of chlorozotocin Nsc-178248), a new nitrosourea antitumor agent.新型亚硝基脲类抗肿瘤药物氯脲霉素（Nsc - 178248）的药理学

Cancer Treat Rep. 1976 Jun;60(6):801-5.

3-(Tetraacetyl glucopyranos-2-yl)-1-(2-chloroethyl)-1-nitrosourea, an antitumor agent with modified bone marrow toxicity.3-（四乙酰基吡喃葡萄糖-2-基）-1-（2-氯乙基）-1-亚硝基脲，一种具有改良骨髓毒性的抗肿瘤药物。

Cancer Res. 1973 Sep;33(9):2005-9.

A structure-activity analysis of chemical and biological parameters of chloroethylnitrosoureas in mice.

Cancer Res. 1977 Aug;37(8 Pt 1):2615-8.

Biological and biochemical properties of the 2-hydroxyl metabolites of 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea.

Cancer Res. 1978 Apr;38(4):1070-4.

引用本文的文献

Bone marrow genotoxicity of N-methyl, N-nitrosourea (NMU): n-alkanols as sister chromatid exchange (SCE) anti-inducers.

Experientia. 1983 Jul 15;39(7):757-9. doi: 10.1007/BF01990311.

In vitro comparative studies of the myelotoxicity and antitumor activity of 6-[bis-(2-chloroethyl)-amino]-6-deoxy-D-glucose versus melphalan utilizing the CFU-C and HTSCA assays.利用CFU-C和HTSCA检测法对6-[双-(2-氯乙基)-氨基]-6-脱氧-D-葡萄糖与美法仑的骨髓毒性和抗肿瘤活性进行的体外比较研究。

Cancer Chemother Pharmacol. 1986;16(2):148-52. doi: 10.1007/BF00256165.

N-methyl antitumour agents. A distinct class of anticancer drugs?N-甲基抗肿瘤药物。一类独特的抗癌药物？

Cancer Chemother Pharmacol. 1987;19(2):91-102. doi: 10.1007/BF00254559.

Chlorozotocin. Mechanism of reduced bone marrow toxicity in mice.氯脲霉素。小鼠骨髓毒性降低的机制。

J Clin Invest. 1979 Oct;64(4):1103-11. doi: 10.1172/JCI109549.

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