Habeck J O
Institut für Pathologie, Städtische Kliniken Chemnitz, Deutschland.
Zentralbl Pathol. 1992 Sep;138(4):303-6.
Reported in this paper are two cases of aggressive perineovulvar angiomyxoma. Soft, painless tumours with gelatinous cut surface were detected in either patient, two women aged 32 and 46 years. Histological findings included fibromyxoid stroma with spindle-shaped and stellate cells as well as vascularization in striking abundance. Most of the vessels were thin-walled. There was no plexiform arborization. Strongly atypical nuclei or mitoses or necrotic foci were not recordable. The tumour exhibited infiltrative growth. Tumour cells could be immunohistochemically associated with antibodies against vimentin, whereas negative responses were recorded from antibodies against S-100 protein, factor-VIII-associated protein and pancytokeratin. Aggressive angiomyxoma is a biologically benign neoplasia prone to recurrence and typically localized in soft tissue of the pelvic region. Metastases so far have never been found. Wide local excision has proved to be the optional therapeutic approach.
本文报道了两例侵袭性会阴外阴血管黏液瘤。两名患者（分别为32岁和46岁的女性）均检测到质地柔软、无痛、切面呈胶冻状的肿瘤。组织学检查结果包括含有梭形和星状细胞的纤维黏液样基质以及丰富的血管形成。大多数血管壁薄。无丛状分支。未记录到明显异型核、有丝分裂或坏死灶。肿瘤呈浸润性生长。肿瘤细胞免疫组化可与波形蛋白抗体结合，而与S-100蛋白、因子VIII相关蛋白和全细胞角蛋白抗体呈阴性反应。侵袭性血管黏液瘤是一种生物学行为良性但易复发的肿瘤，通常位于盆腔软组织。迄今为止尚未发现转移。广泛局部切除已被证明是首选的治疗方法。
