GIBSON R
Can Med Assoc J. 1964 Sep 19;91(12):643-6.
Three cases of de Lange's syndrome are described. This condition is characterized by generally severe mental retardation, reduced stature, mild microcephaly, hypertrichosis, various anomalies of hands and feet, and a peculiar facies. The most outstanding features of the latter are the low forehead, profuse, generally confluent eyebrows, abundant long eyelashes, eyes that frequently slant downwards and outwards in antimongoloid fashion, pug nose with prominent anteverted nostrils, increased distance between nose and vermilion border of upper lip, slight reduction in size of chin, and often abnormally low-placed ears. The etiology of de Lange's syndrome is at present unknown.
本文描述了三例德朗热综合征病例。该病症的特征通常为严重智力发育迟缓、身材矮小、轻度小头畸形、多毛症、手脚的各种异常以及特殊面容。后者最突出的特征是前额低平、眉毛浓密且通常相连、睫毛长而浓密、眼睛常呈反蒙古人种样向下和向外倾斜、朝天鼻且鼻孔前倾突出、鼻与上唇红唇缘之间的距离增加、下巴尺寸略有减小，且耳朵位置常常异常低。德朗热综合征的病因目前尚不清楚。
