一种在双功能螯合剂上引入连接体的便捷且灵活的方法。
A convenient and flexible approach for introducing linkers on bifunctional chelating agents.
作者信息
Studer M, Meares C F
机构信息
Department of Chemistry, University of California, Davis 95616.
出版信息
Bioconjug Chem. 1992 Sep-Oct;3(5):420-3. doi: 10.1021/bc00017a011.
PMID:1420441
Abstract
The synthesis of a protected bifunctional analog of ethylenediaminetetraacetic acid (EDTA) is described. The molecule contains an aminobenzyl moiety that allows the easy attachment of the chelating agent to a wide variety of groups. Examples of reaction with the C-termini of two peptides are given. In the following paper, the two peptides are used to study the enzymatic cleavage of metal chelates from a monoclonal antibody.
摘要
本文描述了一种受保护的乙二胺四乙酸（EDTA）双功能类似物的合成。该分子含有一个氨基苄基部分，这使得螯合剂能够轻松连接到各种各样的基团上。文中给出了与两种肽的C末端反应的示例。在后续论文中，这两种肽被用于研究从单克隆抗体上酶解金属螯合物的过程。
Zotero 插件