Kumar A, Raghubir R, Dhawan B N
Central Drug Research Institute, Lucknow, India.
Neuroreport. 1992 Jul;3(7):591-3. doi: 10.1097/00001756-199207000-00011.
Mild and brief electrical stimulation of sites in the pretectal nucleus (PTN) of rats evoked potent analgesia of long duration, without significant aversions and was unassociated with motor deficit. The present study has analysed effects of opioidergic and cholinergic neurotransmitter antagonists administered intracerebroventricularly (i.c.v.) on this analgesia. Pretreatment either with naloxone or atropine sulphate both in doses of 30 and 50 micrograms each, respectively i.c.v., 10 min prior to subsequent pretectal stimulation, significantly attenuated the increase in tailflick latency. The antagonism of pretectal stimulation produced analgesia (PSPA) by naloxone and atropine, raises the possibility of involvement of both endogenous opioids and cholinergic mechanisms in pretectal analgesia.
对大鼠顶盖前核（PTN）部位进行温和且短暂的电刺激可诱发持续时间较长的强效镇痛，且无明显厌恶反应，也与运动功能障碍无关。本研究分析了脑室内（i.c.v.）注射阿片样物质能和胆碱能神经递质拮抗剂对这种镇痛作用的影响。分别以30微克和50微克的剂量，在随后进行顶盖前刺激前10分钟，脑室内注射纳洛酮或硫酸阿托品进行预处理，显著减弱了甩尾潜伏期的增加。纳洛酮和阿托品对顶盖前刺激产生的镇痛作用（PSPA）的拮抗作用，增加了内源性阿片样物质和胆碱能机制参与顶盖前镇痛的可能性。
