Chia L G, Liu S P, Lee E H
Section of Neurology, Veterans General Hospital, Taichung, Republic of China.
Neuroreport. 1992 Sep;3(9):777-80. doi: 10.1097/00001756-199209000-00014.
The present study examined the effects of deprenyl (1.5 mg kg-1) and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) (30 mg kg-1) on dopamine (DA), norepinephrine (NE) and motor activity in BALB/c mice. Results indicate that pre-treatment with deprenyl injections protected against MPTP's toxicity on DA, NE and motor function. However, if deprenyl was given 3 or 7 days after the MPTP injection (for 3 days in succession), it could not reverse MPTP's toxicity. However, if deprenyl was given for an extended period of 7 days, it reversed MPTP's toxicity on NE, but not on DA and behaviour. If deprenyl was given soon after MPTP each day for 10 days, it protected against MPTP's toxicity on DA and NE, but not on locomotor activity. These results suggest that only prior and repeated deprenyl injection has a satisfactory protective effect against MPTP's neurotoxicity.
本研究考察了司来吉兰（1.5毫克/千克）和1-甲基-4-苯基-1,2,3,6-四氢吡啶（MPTP）（30毫克/千克）对BALB/c小鼠多巴胺（DA）、去甲肾上腺素（NE）和运动活性的影响。结果表明，预先注射司来吉兰可预防MPTP对DA、NE和运动功能的毒性作用。然而，如果在MPTP注射后3天或7天给予司来吉兰（连续给药3天），则无法逆转MPTP的毒性。但是，如果给予司来吉兰7天的延长疗程，它可逆转MPTP对NE的毒性，但对DA和行为无此作用。如果在每天MPTP注射后不久给予司来吉兰，持续10天，它可预防MPTP对DA和NE的毒性，但对运动活性无此作用。这些结果表明，只有预先和重复注射司来吉兰才对MPTP的神经毒性具有令人满意的保护作用。
