BOWMAN W C, CALLINGHAM B A, CUTHBERT A W
Br J Pharmacol Chemother. 1964 Jun;22(3):558-76. doi: 10.1111/j.1476-5381.1964.tb01710.x.
The effects of physostigmine on the electrical and mechanical responses of the nictitating membrane elicited by single nerve shocks have been studied in cats anaesthetized with a mixture of chloralose and pentobarbitone. The results were variable but the most consistent effect, observed with large doses of physostigmine, was a depression and prolongation of the contractions which was sometimes associated with augmentation of the characteristic rhythmic electrical activity of the smooth muscle. Although the amplitude of single responses was depressed, incomplete tetanic contractions were sometimes increased in tension because of the greater fusion which occurred as a result of prolongation of the units of contraction. Possible mechanisms underlying the effect of physostigmine are discussed.
在使用水合氯醛和戊巴比妥混合物麻醉的猫身上，研究了毒扁豆碱对单神经刺激引起的瞬膜电反应和机械反应的影响。结果并不一致，但大剂量毒扁豆碱观察到的最一致的效应是收缩的抑制和延长，这有时与平滑肌特征性节律性电活动的增强有关。尽管单次反应的幅度受到抑制，但由于收缩单位延长导致融合增加，不完全强直收缩的张力有时会增加。文中讨论了毒扁豆碱作用的潜在机制。
