DOSSETOR J B, GAULT M H, OLIVER J A, INGLIS F G, MACKINNON K J, MACLEAN L D
Can Med Assoc J. 1964 Oct 3;91(14):733-42.
Four renal homotransplants were carried out between cadaver donors and four recipients, all of whom were in terminal chronic renal failure. Immune suppression was attempted with azathioprine (Imuran), actinomycin C and prednisone; no radiation was used, nor were the recipient's kidneys, spleen or thymus removed. One patient died with disseminated histoplasmosis at two weeks; another with irreversible homograft rejection at 30 days; a third patient died of septicemia after 9(1/2) weeks with stable renal function. The fourth patient, whose transplant had been ischemic for 190 minutes and had not functioned for 2(1/2) weeks thereafter, eventually achieved good function which remained unchanged to 7(1/2) months. Changes in urinary enzyme excretion and in the I(131) renogram and meralluride scan were of value in assessing homograft rejection.
在尸体供体和四名终末期慢性肾衰竭受体之间进行了四例同种肾移植手术。尝试使用硫唑嘌呤（依木兰）、放线菌素C和泼尼松进行免疫抑制；未使用放疗，也未切除受体的肾脏、脾脏或胸腺。一名患者在两周时死于播散性组织胞浆菌病；另一名在30天时死于不可逆的同种移植排斥反应；第三名患者在肾功能稳定9（1/2）周后死于败血症。第四名患者的移植肾缺血190分钟，此后2（1/2）周无功能，但最终肾功能良好，至7（1/2）个月时仍未改变。尿酶排泄、碘（131）肾图和汞撒利扫描的变化对评估同种移植排斥反应有价值。
