4-甲基三苯甲基（Mtt）：一种用于固相肽合成中天冬酰胺（Asn）和谷氨酰胺（Gln）侧链保护的新型保护基团。
4-Methyltrityl (Mtt): a new protecting group for the side chain protection of Asn and Gln in solid-phase peptide synthesis.
作者信息
Sax B, Dick F, Tanner R, Gosteli J
机构信息
Bachem Feinchemikalien AG, Switzerland.
出版信息
Pept Res. 1992 Jul-Aug;5(4):245-6.
PMID:1421811
Abstract
The trityl group was recently introduced for the protection of the side chain carboxamide function of asparagine and glutamine. The 4-methyltrityl (Mtt) group, a structural modification of trityl, is presented here and allows more rapid cleavage from the protected peptides. Procedures for the introduction of the group and comparative cleavage reactions are also presented.
摘要
三苯甲基基团最近被用于保护天冬酰胺和谷氨酰胺的侧链羧酰胺官能团。本文介绍了三苯甲基的结构修饰——4-甲基三苯甲基（Mtt）基团，它能使受保护的肽更快地裂解。还介绍了该基团的引入方法及比较裂解反应。
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