Olivares M, Llaguno S, Marin V, Hertrampf E, Mena P, Milad M
Hematology Unit, Institute of Nutrition and Food Technology, University of Chile, Santiago.
Acta Paediatr. 1992 Oct;81(10):824-8. doi: 10.1111/j.1651-2227.1992.tb12111.x.
Iron nutrition was measured in 84 low-birth-weight infants. At birth, they were assigned to three groups: preterm infants appropriate for gestational age (n = 29); preterm infants small for gestational age (n = 17); and full-term infants small for gestational age (n = 38). A sub-sample of infants was supplemented with iron 3 mg/kg from two to four months of age. At birth, preterm appropriate-for-gestational-age infants had a lower hemoglobin concentration than full-term small-for-gestational-age infants (p < 0.01) and a higher serum ferritin than preterm small-for-gestational-age infants (p < 0.05). In the non-supplemented group, full-term small-for-gestational-age infants had significantly higher hemoglobin concentrations at four months of age. At this age, iron-supplemented preterm infants appropriate or small for gestational age had significantly higher hemoglobin levels than non-supplemented subjects, while iron supplementation did not have an effect on final hemoglobin concentration in full-term small-for-gestational-age infants. We conclude that preterm infants, irrespective of their adequacy for gestational age, show evidence of iron deficiency before four months of age. Full-term infants do not develop iron deficiency up to this age.
对84名低体重儿进行了铁营养状况检测。出生时，他们被分为三组：适于胎龄的早产儿（n = 29）；小于胎龄的早产儿（n = 17）；以及小于胎龄的足月儿（n = 38）。对一个婴儿亚样本从2至4月龄开始补充3毫克/千克的铁。出生时，适于胎龄的早产儿血红蛋白浓度低于小于胎龄的足月儿（p < 0.01），血清铁蛋白高于小于胎龄的早产儿（p < 0.05）。在未补充铁剂的组中，小于胎龄的足月儿在4月龄时血红蛋白浓度显著更高。在这个年龄，补充铁剂的适于胎龄或小于胎龄的早产儿血红蛋白水平显著高于未补充铁剂的婴儿，而补充铁剂对小于胎龄的足月儿的最终血红蛋白浓度没有影响。我们得出结论，早产儿，无论其是否适于胎龄，在4月龄前均有缺铁迹象。足月儿在这个年龄之前不会出现缺铁情况。
