Gerver W J, Drayer N M, van Es A
Department of Paediatrics, University of Limburg, Maastricht, The Netherlands.
Acta Paediatr. 1992 Sep;81(9):691-4. doi: 10.1111/j.1651-2227.1992.tb12335.x.
The effect of human growth hormone on the body shape of 51 patients with Turner's syndrome (aged 6-19 years) was evaluated. Biosynthetic growth hormone was given in a dose of 24 IU/m2 body surface/week for two years. Karyotype analysis on peripheral blood was performed. Patients older than 12 years also received 0.1 microgram ethinyl oestradiol/kg body weight/day orally. Body shape was characterized by studying pairs of measurements expressed as SD scores (z scores). As reference data, our own locally obtained data from normal children were used. After two years of growth hormone therapy, height, sitting height, bi-acromial and bi-iliac diameter increased from -3.7, -2.9, -1.7 and -1.2 to -1.3, -2.5, -0.6 and +0.5 z scores, respectively. The shape of the patients, expressed as height/bi-iliac diameter and also as sitting height/bi-iliac diameter became more abnormal. As no difference could be noted between the prepubertal and pubertal groups or between the XO and mosaic groups, it is suggested that growth hormone treatment causes a relatively wide pelvis in patients with Turner's syndrome.
评估了人生长激素对51例特纳综合征患者（年龄6 - 19岁）身体形态的影响。给予生物合成生长激素，剂量为24国际单位/平方米体表面积/周，持续两年。对外周血进行核型分析。12岁以上的患者还口服0.1微克炔雌醇/千克体重/天。通过研究以标准差分数（z分数）表示的测量值对来表征身体形态。作为参考数据，使用了我们自己从正常儿童中本地获取的数据。经过两年的生长激素治疗后，身高、坐高、肩峰间径和髂嵴间径分别从 - 3.7、 - 2.9、 - 1.7和 - 1.2 z分数增加到 - 1.3、 - 2.5、 - 0.6和 + 0.5 z分数。患者的身体形态，以身高/髂嵴间径以及坐高/髂嵴间径表示，变得更加异常。由于在青春期前和青春期组之间或XO和嵌合体组之间未发现差异，提示生长激素治疗会导致特纳综合征患者骨盆相对变宽。
