Sisodia S S, Price D L
Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205.
Curr Opin Neurobiol. 1992 Oct;2(5):648-52. doi: 10.1016/0959-4388(92)90033-h.
A principal neuropathological hallmark of Alzheimer's disease is deposition of beta-amyloid, composed primarily of a 4 kD peptide, A beta. This peptide is derived from larger amyloid precursor proteins. The mechanisms that are responsible for A beta formation in vivo are unknown. Recently, transgenic strategies have been employed to test several hypothetical mechanisms in order to reproduce Alzheimer's disease-specific pathology in rodents.
阿尔茨海默病的一个主要神经病理学特征是β-淀粉样蛋白的沉积，其主要由一种4 kD的肽——Aβ组成。这种肽源自更大的淀粉样前体蛋白。体内负责Aβ形成的机制尚不清楚。最近，转基因策略已被用于测试几种假设机制，以便在啮齿动物中重现阿尔茨海默病特异性病理。
