Siegel B V, Asarnow R, Tanguay P, Call J D, Abel L, Ho A, Lott I, Buchsbaum M S
California College of Medicine, University of California, Irvine.
J Neuropsychiatry Clin Neurosci. 1992 Fall;4(4):406-14. doi: 10.1176/jnp.4.4.406.
Sixteen high-functioning adults with a history of childhood autism and 26 normal control subjects underwent [18F]fluoro-2-deoxyglucose positron-emission tomography to assess regional cerebral glucose metabolic rate (GMR). Autistic patients had a left > right anterior rectal gyrus asymmetry, as opposed to the normal right > left asymmetry in that region. Patients also showed low GMR in the left posterior putamen and high GMR in the right posterior calcarine cortex. Brain regions with GMR > 3 SD from the normal mean were more prevalent in patients than in control subjects. This variable pattern of abnormal activity is consistent with heterogeneous neurophysiological etiology; group differences in striatum and cortex may represent a final common pathway.
16名有儿童期孤独症病史的高功能成年人以及26名正常对照受试者接受了[18F]氟-2-脱氧葡萄糖正电子发射断层扫描，以评估局部脑葡萄糖代谢率（GMR）。孤独症患者存在左侧>右侧直肠前回不对称，而该区域正常人为右侧>左侧不对称。患者还表现出左侧壳核后部GMR降低以及右侧距状后皮质GMR升高。GMR高于正常均值3个标准差的脑区在患者中比在对照受试者中更常见。这种异常活动的可变模式与异质性神经生理病因一致；纹状体和皮质的组间差异可能代表了最终的共同通路。
