网状细胞增多症患者血清α-2球蛋白的变化
CHANGES IN SERUM ALPHA-2 GLOBULINS IN RETICULOSES.
作者信息
MALPAS J S, FAIRLEY G H
出版信息
J Clin Pathol. 1964 Nov;17(6):651-4. doi: 10.1136/jcp.17.6.651.
The total concentrations of alpha(2) globulin and two of its components, haptoglobin and caeruloplasmin, have been determined in the sera from 78 patients with primary malignant diseases of lympho-reticular tissue (reticuloses). The total alpha(2) globulin fraction was significantly raised only in Hodgkin's disease. The serum haptoglobin was also significantly increased in Hodgkin's disease and some other reticuloses, including acute leukaemia, lymphosarcoma, and reticulum cell sarcoma. The serum level of caeruloplasmin was raised in all reticuloses. There was possibly some correlation between the rise in haptoglobin and caeruloplasmin concentrations and the total alpha(2) globulin in Hodgkin's disease but this was not statistically significant. The significance of these results is discussed, and it is concluded that the increase in alpha(2) globulin which occurs in Hodgkin's disease is due to an increase in several of its components and not to a single component.
已对78例淋巴网状组织原发性恶性疾病（网状细胞增多症）患者血清中的α(2)球蛋白及其两种成分（触珠蛋白和铜蓝蛋白）的总浓度进行了测定。仅在霍奇金病中，α(2)球蛋白总分数显著升高。霍奇金病以及其他一些网状细胞增多症（包括急性白血病、淋巴肉瘤和网状细胞肉瘤）患者的血清触珠蛋白也显著增加。所有网状细胞增多症患者的血清铜蓝蛋白水平均升高。在霍奇金病中，触珠蛋白和铜蓝蛋白浓度的升高与α(2)球蛋白总量之间可能存在某种相关性，但这在统计学上并不显著。本文讨论了这些结果的意义，并得出结论，霍奇金病中出现的α(2)球蛋白增加是由于其几种成分的增加，而非单一成分所致。
Zotero 插件