Mignonsin D, Tavares D A, Kane M, Bondurand A
Département d'Anesthésie, Abidjan, RCI.
Cah Anesthesiol. 1992;40(5):337-41.
The aim of this study was to compare spinal anaesthesia with 0.5% bupivacaine at 20 degrees C and 5 degrees C. One hundred two patients ASA I-II were randomized into two groups. After atropine and IV fluid administration, patients of group I received intrathecally at L3-L4 level 0.02 ml.cm-1 of plain 0.5% bupivacaine at 20 degrees C, while patients of group II received the same solution and the same doses but at 5 degrees C. No significant difference was found between the times for installation of sensory and motor blocks nor between the durations of motor block in the two groups. On the other hand significant differences were found between the durations of sensory block in group I (283.33 min +/- 9.40 min) and group II (314.35 +/- 8.80 min) (P < 0.001) and all the more (P < 10(-9)) between the cephalad block extensions in group I (D 7.45 +/- 0.14) and group II (D 4.82 +/- 0.20). Therefore plain bupivacaine 0.5%, isobaric at 20 degrees C, seems to get the properties of an hyperbaric solution when cooled at 5 degrees C.
本研究的目的是比较20℃和5℃时0.5%布比卡因的脊髓麻醉效果。102例ASA I-II级患者被随机分为两组。给予阿托品和静脉输液后，I组患者在L3-L4水平鞘内注射20℃的0.5%布比卡因原液，剂量为0.02 ml·cm-1，而II组患者接受相同溶液和相同剂量，但温度为5℃。两组在感觉和运动阻滞起效时间以及运动阻滞持续时间方面均未发现显著差异。另一方面，I组（283.33分钟±9.40分钟）和II组（314.35±8.80分钟）的感觉阻滞持续时间之间存在显著差异（P<0.001），I组（D 7.45±0.14）和II组（D 4.82±0.20）的头端阻滞范围之间差异更显著（P<10-9）。因此，20℃时等比重的0.5%布比卡因原液在冷却至5℃时似乎具有重比重溶液的特性。
