MCGUFF P E, DETERLING R A, GOTTLIEB L S, FAHIMI H D, BUSHNELL D, ROEBER F
Can Med Assoc J. 1964 Nov 21;91(21):1089-95.
Some of the results of experiments performed during the past two years to assess effects of laser energy on experimental malignant tumours are reviewed. Twenty types of malignant tumours (most in the cheek pouch and 11 of human origin) were treated in over 700 Syrian hamsters. Results of laser treatment of malignant melanomas and thyroidal carcinomas are presented. A human patient with malignant melanoma treated by laser energy is described. Investigation of thermal effect revealed that the laser-treated tumour remained warm for about one minute, while the cautery-treated tumour cooled to normal temperature in five seconds. Direct action of laser on superficial tumours is possible; deeper lesions must be exposed surgically. Laser energy has a selective effect on certain malignant tumours, resulting in their progressive regression and ultimate dissolution. All hamsters with implanted malignant melanomas and carcinomas of human origin, after completion of a course of laser treatment, showed no gross or histologic evidence of tumour up to the date of last observation.
本文回顾了过去两年间为评估激光能量对实验性恶性肿瘤的影响而进行的一些实验结果。在700多只叙利亚仓鼠身上治疗了20种恶性肿瘤（大多数位于颊囊，其中11种源于人类）。文中给出了激光治疗恶性黑色素瘤和甲状腺癌的结果。还描述了一名接受激光能量治疗的恶性黑色素瘤人类患者。热效应研究表明，激光治疗的肿瘤大约保持一分钟温暖，而烧灼治疗的肿瘤在五秒内冷却至正常温度。激光可直接作用于浅表肿瘤；较深的病变必须通过手术暴露。激光能量对某些恶性肿瘤有选择性作用，导致其逐渐消退并最终溶解。所有植入人类恶性黑色素瘤和癌的仓鼠，在完成一个激光治疗疗程后，直至最后观察日期，均未显示出肿瘤的肉眼或组织学证据。
