Powell H C, Elliott M L
Virchows Arch A Pathol Anat Histol. 1977 Jun 23;374(3):197-203. doi: 10.1007/BF00427114.
Congenital lobar emphysema is reported occurring in a 10 day old, low birth weight infant. Following resection, gross examination of the affected lobe revealed collapsed but unobstructed bronchi, suggesting a cartilaginous defect. The specimen was insufflated with formalin and the bronchial tree dissected out. Histological study including comparison with a normal pulmonary lobe, confirms that abnormalities of cartilage may be important in the pathogenesis of congenital lobar emphysema.
据报道，一名出生10天、低体重的婴儿患有先天性大叶性肺气肿。切除术后，对受影响的肺叶进行大体检查，发现支气管塌陷但无阻塞，提示存在软骨缺陷。将标本用福尔马林灌注，并解剖出支气管树。包括与正常肺叶比较的组织学研究证实，软骨异常可能在先天性大叶性肺气肿的发病机制中起重要作用。
