HEDGECOCK L W
J Bacteriol. 1964 Nov;88(5):1349-55. doi: 10.1128/jb.88.5.1349-1355.1964.
Hedgecock, Loyd W. (Veterans Administration Hsopital, St. Louis, Mo.). Resistance-enhancing activity of culture filtrates of Mycobacterium tuberculosis. J. Bacteriol. 88:1349-1355. 1964.-It was demonstrated that filtrates of cultures of Mycobacterium tuberculosis exhibit resistance-enhancing activity against infection with Klebsiella pneumoniae and Diplococcus pneumoniae. Resistance was demonstrable when the culture filtrate was injected 3 hr prior to challenge with K. pneumoniae, and reached the highest level when injected 24 hr before challenge. Protection was maximal when the filtrate and challenging organisms were injected by the same route. After infection with K. pneumoniae, the bacterial titers in the tissues of filtrate-treated animals were significantly lower than those of untreated susceptible controls. Mice injected with the filtrate 24 hr previously demonstrated significantly increased rates of clearance of injected carbon from the blood. In examination of a variety of mycobacteria, resistance-enhancing activity was found only in culture-filtrates of pathogenic mycobacteria, the highest concentration occurring in filtrates of virulent organisms. The injection of a relatively large amount of phenol-killed cells of all of the mycobacteria examined enhanced resistance to infection with K. pneumoniae.
赫奇科克，洛伊德·W.（密苏里州圣路易斯市退伍军人管理局医院）。结核分枝杆菌培养滤液的增强抵抗力活性。《细菌学杂志》88:1349 - 1355。1964年。- 已证明结核分枝杆菌培养滤液对肺炎克雷伯菌和肺炎双球菌感染具有增强抵抗力的活性。当在肺炎克雷伯菌攻击前3小时注射培养滤液时，可证明有抵抗力，在攻击前24小时注射时抵抗力达到最高水平。当滤液和攻击菌通过相同途径注射时，保护作用最大。感染肺炎克雷伯菌后，经滤液处理的动物组织中的细菌滴度明显低于未处理的易感对照。24小时前注射滤液的小鼠显示出血液中注入碳的清除率显著提高。在对多种分枝杆菌的检查中，仅在致病性分枝杆菌的培养滤液中发现增强抵抗力的活性，最强浓度出现在有毒力生物体的滤液中。注射相对大量经苯酚杀死的所有所检查分枝杆菌细胞可增强对肺炎克雷伯菌感染的抵抗力。
