DAVENPORT F M, HENNESSY A V, DRESCHER J, MULDER J, FRANCIS T
J Exp Med. 1964 Dec 1;120(6):1087-97. doi: 10.1084/jem.120.6.1087.
By use of a photometric method which objectively distinguishes between homologous and heterologous antibody reactions, the age distribution of specifically reacting swine and Asian antibodies present in sera of persons not recently exposed to either virus was established. The findings support the thesis that the unique distribution by age of swine and Asian antibodies recognizes two past periods of prevalence of swine and Asian-like viruses, respectively. The findings apparently refute the conclusion that the existence of age-specific Asian and swine antibody patterns is primarily attributable to the undirected or passive accumulation of experience with Asian or swine antigens present as minor antigenic components in most strains of influenza A.
通过使用一种能客观区分同源和异源抗体反应的光度测定法,确定了近期未接触过这两种病毒的人群血清中特异性反应的猪抗体和亚洲抗体的年龄分布。这些发现支持了这样一种论点,即猪抗体和亚洲抗体按年龄的独特分布分别识别了猪病毒和类亚洲病毒过去的两个流行期。这些发现显然反驳了以下结论,即亚洲抗体和猪抗体的年龄特异性模式的存在主要归因于在大多数甲型流感病毒株中作为次要抗原成分存在的亚洲或猪抗原的无定向或被动积累。