Davenport F M, Hennessy A V, Minuse E
J Exp Med. 1967 Dec 1;126(6):1049-61. doi: 10.1084/jem.126.6.1049.
The antibody pattern of equine-2/63 viruses has been more sharply defined using a large number of human sera collected in 1964. The birth dates of persons exhibiting the richest experience with equine-2/63-like viruses delineate a period of past prevalence in man of equine-2/63-like viruses. The period is believed to have begun in the mid-1870's and to have terminated in 1889-1890 at the time of the first Asian pandemic. The equine-2/63 antibodies found in human sera react specifically in the photometric test of Drescher. The equine-2/63 antibody pattern advances along the age scale in exact concordance with the passage of time. The homologous antibody response of the older subjects to equine-2/63 vaccine is more vigorous, reflecting the conditioning effects of prior exposures to equine-2/63 antigens. A "one-way cross" between equine-2/63 virus and A(2) and A(1) strains has been demonstrated. The antigenic ties between strains of influenza A isolated from humans, swine, horses, and birds is recognized and discussed. It is apparent that horses do not constitute an active reservoir for strains of human involvement. The epidemiologic significance of the antigenic linkages between strains isolated from different species remains obscure.
利用1964年收集的大量人类血清,马-2/63病毒的抗体模式已得到更清晰的界定。那些对马-2/63样病毒有最丰富接触经历的人的出生日期划定了马-2/63样病毒过去在人类中流行的一个时期。据信这个时期始于19世纪70年代中期,并在1889 - 1890年首次亚洲大流行时结束。在人类血清中发现的马-2/63抗体在德雷舍尔的光度测试中具有特异性反应。马-2/63抗体模式随着年龄增长而发展,与时间的推移完全一致。年龄较大的受试者对马-2/63疫苗的同源抗体反应更强烈,这反映了先前接触马-2/63抗原的影响。已证实马-2/63病毒与A(2)和A(1)毒株之间存在“单向交叉”。人们认识并讨论了从人类、猪、马和鸟类中分离出的甲型流感毒株之间的抗原联系。显然,马并非人类相关毒株的活跃储存宿主。从不同物种分离出的毒株之间抗原联系的流行病学意义仍不清楚。