高渗（7.5%）盐水输注对右心室梗死所致心源性休克患者的急性血流动力学影响。

Acute hemodynamic effects of hypertonic (7.5%) saline infusion in patients with cardiogenic shock due to right ventricular infarction.

作者信息

Ramires J A, Serrano Júnior C V, César L A, Velasco I T, Rocha e Silva Júnior M, Pileggi F

机构信息

Heart Institute, Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo, Brazil.

出版信息

Circ Shock. 1992 Jul;37(3):220-5.

PMID:1423912

Abstract

The hemodynamic effects, after infusion of 4 ml/kg of hypertonic (7.5%) saline solution (HS), were evaluated in six patients (mean age = 56.6 years) with cardiogenic shock (CS) due to right ventricular infarction (RVI). Basal condition data (mean +/- SEM) were as follows: cardiac index (CI) = 1.9 +/- 0.1 1/min/m2, arterial pressure (AP) = 66.5 +/- 0.9 mmHg, and systemic vascular resistance (SVR) = 31.3 +/- 1.0 mmHg/1/min/m2. Five- and 240-minute post-HS infusion data (respectively) revealed: CI = 3.3 +/- 0.1* and 2.9 +/- 0.1* 1/min/m2, AP = 87.7 +/- 1.6* and 80.7 +/- 2.2* mmHg, and SVR = 22.5 +/- 0.6* and 24.5 +/- 1.1* mmHg/1/min/m2 (*P less than 0.05 compared to baseline values). These data suggest that small-volume infusion of HS induced an important acute and sustained hemodynamic improvement in these patients with CS due to RVI.

摘要

对6例因右心室梗死（RVI）导致心源性休克（CS）的患者（平均年龄 = 56.6岁）输注4 ml/kg高渗（7.5%）盐溶液（HS）后的血流动力学效应进行了评估。基础状态数据（平均值±标准误）如下：心脏指数（CI）= 1.9±0.1 l/min/m²，动脉压（AP）= 66.5±0.9 mmHg，全身血管阻力（SVR）= 31.3±1.0 mmHg/l/min/m²。HS输注后5分钟和240分钟的数据（分别）显示：CI = 3.3±0.1* 和2.9±0.1* l/min/m²，AP = 87.7±1.6* 和80.7±2.2* mmHg，SVR = 22.5±0.6* 和24.5±1.1* mmHg/l/min/m²（*与基线值相比，P<0.05）。这些数据表明，小剂量输注HS可使这些因RVI导致CS的患者的血流动力学得到重要的急性和持续性改善。