von den Driesch P, Fartasch M, Hornstein O P
Department of Dermatology, University Erlangen-Nürnberg, Germany.
Clin Exp Dermatol. 1992 Jan;17(1):38-43. doi: 10.1111/j.1365-2230.1992.tb02532.x.
This report describes two patients suffering from severe chronic actinic dermatitis. Unusual widespread vitiligo-like depigmentation occurred during the course of the disease. The progression of these lesions was triggered by the chronic actinic dermatitis. Loss of pigment and complete absence of tyrosinase positive melanocytes were found in depigmented skin of both cases. Immunohistological investigation of the inflammatory infiltrate in case 2 revealed a predominance of CD-8 positive cytotoxic/-suppressor lymphocytes. Analysing the adjacent pigmented epidermis of progressive depigmenting lesions a dense exocytosis of CD-8 T-cells was notable. This distribution suggests cytotoxic destruction of melanocytes as the cause for the vitiligo-like depigmentation.
本报告描述了两名患有严重慢性光化性皮炎的患者。在疾病过程中出现了不寻常的广泛白癜风样色素脱失。这些皮损的进展是由慢性光化性皮炎引发的。在两例患者的色素脱失皮肤中均发现色素缺失且完全没有酪氨酸酶阳性黑素细胞。对病例2炎症浸润的免疫组织学研究显示CD-8阳性细胞毒性/抑制性淋巴细胞占优势。分析进行性色素脱失皮损相邻的色素沉着表皮，可见CD-8 T细胞密集的胞吐作用。这种分布表明黑素细胞的细胞毒性破坏是白癜风样色素脱失的原因。
