Klok A M, Geertzen R, Rothova A, Baarsma G S, Kijlstra A
Department of Ophthalmology, Free University of Amsterdam, The Netherlands.
Curr Eye Res. 1992;11 Suppl:209-13. doi: 10.3109/02713689208999535.
Anticardiolipin antibodies (ACA) have been described in association with thrombosis and several vascular diseases and may be involved in retinal vasculitis. To investigate this question we tested sera from 86 patients with posterior uveitis and 100 healthy controls for the presence of anticardiolipin antibodies. The antibody was present in 15 patients: in 7 of the patients with acute retinal necrosis (n = 24), in 4 with idiopathic retinal vasculitis (n = 10), 3 with syphilis (n = 6) and in one SLE patient with retinal vasculitis. Ten patients had IgA-type anticardiolipin antibodies, 6 had IgM-type and 4 had IgG-type anticardiolipin antibodies. Anticardiolipin antibodies could not be detected in sera from uveitis patients with Behçet's disease (n = 10), sarcoid (n = 9), toxoplasmosis (n = 7), multiple sclerosis (n = 3) or Birdshot chorioretinopathy (n = 10). Ten of the healthy controls had cardiolipin antibodies of the IgM class. The exact role of these auto-antibodies in the pathogenesis of retinal vasculitis remains to be resolved.
抗心磷脂抗体（ACA）已被描述与血栓形成及多种血管疾病相关，且可能参与视网膜血管炎。为研究此问题，我们检测了86例后葡萄膜炎患者和100例健康对照者血清中抗心磷脂抗体的存在情况。15例患者存在该抗体：24例急性视网膜坏死患者中有7例，10例特发性视网膜血管炎患者中有4例，6例梅毒患者中有3例，以及1例患有视网膜血管炎的系统性红斑狼疮（SLE）患者。10例患者有IgA型抗心磷脂抗体，6例有IgM型，4例有IgG型抗心磷脂抗体。在白塞病（10例）、结节病（9例）、弓形虫病（7例）、多发性硬化症（3例）或小柳原田病（10例）的葡萄膜炎患者血清中未检测到抗心磷脂抗体。10例健康对照者有IgM类心磷脂抗体。这些自身抗体在视网膜血管炎发病机制中的确切作用仍有待解决。
