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Differential sensitivity of cardiac K+(ATP) channels to guanine nucleotides--evidence for a heterogeneous channel population.

作者信息

Benz I, Kohlhardt M

机构信息

Physiological Institute, University Freiburg, Federal Republic of Germany.

出版信息

Eur Biophys J. 1992;21(4):299-302. doi: 10.1007/BF00185124.

DOI:10.1007/BF00185124
PMID:1425481
Abstract

In cell-free patches from cultured neonatal rat cardiocytes, the cytosolic presence of GTP-gamma-S (100 mumol/l) or GDP-beta-S (100 mumol/l) activated K+(ATP) channels. GTP-gamma-S required cytosolic Mg++, suggesting that an activated G-protein causes the increase in open probability. The great variations of the channel response to GTP-gamma-S and GDP-beta-S indicates that cardiac K+(ATP) channels represent a heterogeneous family.

摘要

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本文引用的文献

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